Cardiac Calcium Dynamics

Intracellular Calcium is the central regulator of cardiac contractility

Slide 3

Cardiac cells - EC Coupling

Nonfailing Versus Failing Human Hearts

Observations about Failing Hearts in Piacentino, et al.

Slide 7

Problem Formulation

Nonfailing Versus  Failing Heart

Peak Comparison of RyR-Gating

Transient Behavior of Calcium

Model with Voltage-Gated L-Channel

Conclusions

Good Ideas, Bad Results

Possible Improvements

"Brynja Kohler"