The Dynamics of Growing Biofilm

Biofilms

Some of the Interesting and Important Questions

Biofilm formation in Pseudomonas Aeruginosa

The Dynamics of Growing Biofilm

Quorum Sensing in P. Aeruginosa

Quorum sensing in P. Aeruginosa

“Wall Sensing” in P. Aeruginosa

The Dynamics of Growing Biofilm

The Biochemistry of Quorum Sensing

An ODE Model

Modeling Biochemical Reactions with ODE’s

Slide 13

Slide 14

Slide 15

An even simpler model

A Simple Model for Wall Sensing

A Simple Model for Wall Sensing - cont’d

A Proper (PDE) Model

Autoinducer with fixed colony size, variable density

Autoinducer concentration; fixed density, variable size colony

Heterogeneous Structures

A Hydrogel Primer

Fibrin Network (Blood Clot)

A Hydrogel Primer - II

How gels grow

Modeling Biofilm Growth

Force Balance

Osmotic Pressure

Phase Separation

Movement by Swelling

Propulsion by Swelling

No gel; no swell

Heterogeneous Structures

“Limited Resource” Instability

Channeling

Slide 37

Channeling

Conclusions

More Questions (than answers)