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Outline
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Heat-Shock Response
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Mechanisms Modeled
"Competition among
DnaK and RNAP..."
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Stochastic vs.
Deterministic
Stochastic Simulation
Algorithm
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Analysis of the HS System
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Effect of Sequestration on
Sensitivity
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Role of the degradation
loop in attenuating stochastic fluctuations
Linearized Heat Shock
Models
H2 norm
(variance) Computations
Comparison of the Two
Models
SSA Results and Comparison
of the Two Modes of Regulation
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Model Reduction: General
Principles for Biological Systems
The Reduced Heat Shock
Model
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Known Biology vs. Phenotype
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Missing Players?
Model Invalidation
Model Invalidation using
SOStools
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Is the WT Response optimal?
"Cost function:"
Pareto Optimal Design of
the Heat Shock System
New Tools
Control Theory in
Biological Systems
"New understanding of
regulation in..."
Acknowledgements