Poxviruses and Adaptive Genome Evolution

Genome Evolution

Genome Evolution

Genome Evolution

Genome Evolution

Genome Evolution

Genome Structure

Multiple Genome Comparison

Pox virus genomes

Poxviruses

Questions:

Questions:

Orthologue detection

Slide 14

"Complete linkage"

Complete linkage

Single-link clustering

Slide 18

Orthologues

Conserved gene order and spacing

Poxvirus Phylogeny

Poxvirus Phylogeny

Orthopox phylogeny

Counting gene gain and loss

Phylogenomic Approach

Infer gene gain along the branch to the most recent common ancestor

Infer gene loss parsimoniously

Numbers of gain/loss events

Numbers of gain/loss events

Rate of Gene Gain

Rate of Gene Gain

Rate of Gene Gain

Slide 33

Increased Gene Gain in the Orthopox Lineage

Increased Gene Gain in the Orthopox Lineage

Sources of Gene Acquisition

Horizontal Transfer

Horizontal Transfer

Gene loss modelling

Gene loss events

Adaptive Evolution

Standard Genetic Code

Detection of Positive Selection

Detection of Positive Selection

Detection of Positive Selection

Detection of Positive Selection

Detection of Positive Selection

Positive Selection on Pox Genes

Positive Selection on Pox Genes

Adaptive Genome Evolution?

Adaptive Genome Evolution?

Conclusions

Acknowledgements