How comparative genomic helps finding
selenoproteins

what are selenoproteins?

the selenocysteine codon?

the selenocysteine codon:UGA

recoding of UGA

the dual function of UGA compounds the identification of  selenoproteins

Selenoprotein search: SECIS search

SECIS search: PatScan

SECIS search in the Drosophila genome

selenoprotein search:
codon bias

selenoprotein search: codon bias

selenoprotein search:
SECIS + codon bias

selenoprotein search in Drosophila
(Castellano et al. EMBO Reports 2:697-702, 2001)

dSelG

dSelM

dSelG and dSelM are ubiquitous selenoproteins

dSelG has selenoprotein homologues in vertebrates

selenoprotein search in mammalian genomes

conserved SECIS between human and mouse

Slide 20

selenoprotein search in other vertebrate genomes

human vs. fugu

SelU: a novel selenoprotein family
(Castellano et al., EMBO reports, revised)

SelU: scattered phylogenetic distribution

the eukaryotic selenoproteome

"IMIM,"