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Yersinia Type III secretion system

Approach

Unusual similarities between Bacteria & Eukaryote genes:
Sequence similarity-based approach

Unusual similarities between Bacteria & Eukaryote genes:
Sequence similarity-based approach

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Genome   data for…

Bacterial Pathogens

Trends in this Sequence-based Analysis

Trends in this Sequence-based Analysis

First case: Bacterium    Eukaryote Lateral Transfer

N-acetylneuraminate lyase – role in pathogenicity?

N-acetylneuraminate lyase (sialic acid lyase, NanA)

Another case: A Sensor Histidine Kinase for a
Two-component  Regulation System

Streptomyces Histidine Kinase. The Missing Link?

“Plant-like” genes in Chlamydia

“Plant-like” genes in Chlamydia

“Plant-like” genes in Chlamydia

“Plant-like” genes in Chlamydia

Chlamydiaceae share an ancestral relationship with Cyanobacteria and Chloroplast

Chlamydiaceae share an ancestral relationship with Cyanobacteria and Chloroplast

Chlamydiaceae “plant-like” genes reflect an ancestral relationship with Cyanobacteria and the Chloroplast

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Horizontal Gene Transfer and Bacterial Pathogenicity

Pathogenicity Islands

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Dinucleotide bias analysis

Dinucleotide bias analysis

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What features best predict Islands?

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Properties of genes in these islands?

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Summary: Bacteria gene transfer analysis

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Implications: Evolution of Pathogenicity

Pathogens and “The Art of War”

Functional Pathogenomics of Mucosal Immunity

"BC Pathogenomics group"