Yersinia Type III secretion system
Unusual similarities between
Bacteria & Eukaryote genes:
Sequence similarity-based approach
Unusual similarities between
Bacteria & Eukaryote genes:
Sequence similarity-based approach
Trends in this Sequence-based Analysis
Trends in this Sequence-based Analysis
First case: Bacterium Eukaryote Lateral Transfer
N-acetylneuraminate lyase – role in pathogenicity?
N-acetylneuraminate lyase (sialic acid lyase, NanA)
Another case: A Sensor
Histidine Kinase for a
Two-component Regulation System
Streptomyces Histidine Kinase. The Missing Link?
“Plant-like” genes in Chlamydia
“Plant-like” genes in Chlamydia
“Plant-like” genes in Chlamydia
“Plant-like” genes in Chlamydia
Chlamydiaceae share an ancestral relationship with Cyanobacteria and Chloroplast
Chlamydiaceae share an ancestral relationship with Cyanobacteria and Chloroplast
Horizontal Gene Transfer and Bacterial Pathogenicity
What features best predict Islands?
Properties of genes in these islands?
Summary: Bacteria gene transfer analysis
Implications: Evolution of Pathogenicity
Pathogens and “The Art of War”