A comparative approach for gene network inference using time-series gene expression data

DNA Microarrays

Gene Expression Data

Beyond Clustering…

Comparative Framework

Harder Problem?

Outline

Gene Network Model

Small Network Example

Small Network Example

Small Network Example

Problem Revisited

Linear Differential Equations

Algorithm for Network Inference

Partial F Test

Simulations

Gaussian Noise

Network Inference

10 Genes

Multiple Networks

Types of Problems

Evolutionary Cost

Multiple Network Inference

Simulation Example

Simulation Example

Simulation Results

Conclusions