IMA Postdoc Seminar (October 9, 2007)

Speaker: Timothy Newman (Arizona State University)

Title: Modeling multicellularity: from cell rheology to gastrulation

Abstract: I will present an overview of recent work focused on constructing computer models of developmental systems. In particular, we have constructed an algorithm, called the Subcellular Element Model, which is able to simulate large numbers (thousands) of deformable cells in three dimensions. I will describe the inner workings of the algorithm, and indicate that the method is capable of modeling developmental systems over a wide range of scales - capturing cell visco-elasticity at small scales, and long-ranged coordinated cell movement at large scales. Modeling of primitive streak extension in the chick embryo will be discussed as a concrete application.