| 8:30-10 | General Lecture |
| 10-10:30 | Break |
| 10:30-12 | General Lecture |
| 12-1 | Lunch |
| 1-2 | Topical Lecture |
| 2-2:30 | Break |
| 2:30-4:30 | Problem/Brainstorming Session |
| Day | Lecture 1 | Lecture 2 | Topical Lecture | Problem Ideas |
| #1 | Introductions | Bacterial | Jim Keener | quorum sensing |
| 16 | Enzyme kinetics | chemotaxis | biochemical switches | in V.fisheri |
| lac operon | ||||
| #2 | Cellular homeostasis | molecular | Kathryn Tosney | homeostasis of |
| 17 | motors I | growth cone | T. californicus | |
| motility | ||||
| #3 | Channels, Gates | molecular | Alex Mogilner | survival mechanism |
| 18 | Transporters | motors II | model of cell crawling: | of h. pylori |
| nematode sperm cell | ||||
| #4 | Excitability | muscle | TBA | iron metabolism in |
| 19 | HH Theory | contraction | T. ferroxidans | |
| #5 | Calcium | physics of | Lihsia Chen | (no problem |
| 20 | EC Coupling | biological gels | cell adhesion | session today) |
| #6 | Cell Cycle | cell | Robert Sheaff | regul.&differ. |
| 23 | migration | cell cycle control | of urothelial cells | |
| #7 | Axons and Waves | neutrofil | Clifton Ragsdale | calcium waves |
| 24 | chemotaxis | neural connection | in C. elegans | |
| #8 | Intercellular | large gen&biochem | Ron Siegel | action poten. propag. |
| 25 | communication | networks | gel drug delivery | in frog myocytes |
| #9 | Bursting | modeling | Bob Tranquillo | genetic basis of |
| 26 | Biochem. oscill. | morphogenesis | chemotaxis | circadian rhythms |
| circadian cycles | ||||
| #10 | Biochemical signalling | morphogenesis | TBA: | (no problem |
| 27 | cAMP, E. coli | in Drosophila | participant talk | session today) |
Titles:
Ron Siegel
MODELS OF AN AUTONOMOUS RHYTHMIC HORMONE DELIVERY SYSTEM
Certain disorders in sexual development and reproductive function are traced to disorders in the rhythmic, pulsatile secretion of gonadotropin releasing hormone (GnRH) from the hypothalamus. These disorders may require long-term hormone replacement therapy, and rhythmic delivery of GnRH is essential. Since GnRH is exceptionally potent, implantable hormone delivery systems may be considered. We are developing such a system, in which autonomous modulation of permeability of a hydrogel membrane to GnRH is driven by endogenous glucose, via a chemomechanical limit cycle established by feedback between the membrane and an enzyme. Several mathematical models of this system have been developed, with different levels of complexity. We will present results of a lumped, ODE-based model, for which the bifurcation structure has been worked out, and will also progress towards a more detailed, distributed (PDE-based) model.