Slide 1

Outline

Who am I?

Quantitative Analysis and Modulation of the Spatial Operation of the EGF Receptor Autocrine Cell Signaling System

Slide 5

Dysregulation of autocrine communication can lead to disease.

Two extremes of autocrine cell operation:

Slide 8

Slide 9

Slide 10

We then convert this mental picture into mathematics…

A system of equations with measurable parameters, initial conditions, & outputs.

Mathematical models are validated with experimentation

Slide 14

Testing experimental hypotheses is time-intensive with living systems…

Slide 16

Cells can modulate spatial distribution of signals via processes governing signal rate, receptor number, and binding affinity.

Closing section #2 …

Outline

Slide 20

Why is 3M Pharmaceuticals somewhat unique?

Making good decisions is a critical activity in any competitive industry.

Many groups within 3M Pharmaceuticals making decisions

Genomics

Slide 25

Slide 26

Why is System Knowledge difficult to attain?

The Scientific Process

Drivers?

Slide 30

Systems Biology

Example from Davidson et al. Science 295, pp. 1669-1678, 2002.

Systems Biology: the intersection of biology, engineering & mathematics, & IT

Systems Biology cont.

Who (of Pharma/Biotech companies) has efforts in systems biology?

In silico Biology Companies
 (not ADME/Tox and Pharmacokinetic Models)

Closing section #3 & 4 …

Opportunities for Mathematics in Pharmaceutical Industry

Skill sets for Successful Career

Acknowledgements