Who am I?
Quantitative Analysis and Modulation of the Spatial Operation of the EGF Receptor Autocrine Cell Signaling System
Dysregulation of autocrine communication can lead to disease.
Two extremes of autocrine cell operation:
We then convert this mental picture into mathematics…
A system of equations with measurable parameters, initial conditions, & outputs.
Mathematical models are validated with experimentation
Testing experimental hypotheses is time-intensive with living systems…
Cells can modulate spatial distribution of signals via processes governing signal rate, receptor number, and binding affinity.
Closing section #2 …
Why is 3M Pharmaceuticals somewhat unique?
Making good decisions is a critical activity in any competitive industry.
Many groups within 3M Pharmaceuticals making decisions
Why is System Knowledge difficult to attain?
The Scientific Process
Example from Davidson et al. Science 295, pp. 1669-1678, 2002.
Systems Biology: the intersection of biology, engineering & mathematics, & IT
Systems Biology cont.
Who (of Pharma/Biotech companies) has efforts in systems biology?
In silico Biology
(not ADME/Tox and Pharmacokinetic Models)
Closing section #3 & 4 …
Opportunities for Mathematics in Pharmaceutical Industry
Skill sets for Successful Career