Dysregulation of autocrine communication can lead to disease.
Two extremes of autocrine cell operation:
We then convert this mental picture into mathematics…
A system of equations with measurable parameters, initial conditions, & outputs.
Mathematical models are validated with experimentation
Testing experimental hypotheses is time-intensive with living systems…
Why is 3M Pharmaceuticals somewhat unique?
Making good decisions is a critical activity in any competitive industry.
Many groups within 3M Pharmaceuticals making decisions
Why is System Knowledge difficult to attain?
Example from Davidson et al. Science 295, pp. 1669-1678, 2002.
Systems Biology: the intersection of biology, engineering & mathematics, & IT
Who (of Pharma/Biotech companies) has efforts in systems biology?
In silico Biology
Companies
(not ADME/Tox and
Pharmacokinetic Models)
Opportunities for Mathematics in Pharmaceutical Industry