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Talk abstract:
The role of modeling in the design of antitachycardia implantable devices
Eddy Warman, Medtronic Inc.
Despite the success of implantable devices in the termination of cardiac
tachyarrhythmias, these devices have not met yet their full potential.
Reliable pace termination of tachyarrhythmias is one of the most desired
improvements for current devices. Today, many tachyarrhythmias are
ultimately terminated by high current shocks that are not well tolerated by
patients. Termination of tachyarrhythmias by unperceived low current pacing
pulses is currently possible on highly periodic rhythms. Reliable pace
termination of a wide class of rhythms remains one of the biggest
challenges of today. Past experiments have been difficult to interpret due
to high experimental variability and limited knowledge of the dynamic
system. Presently, computer simulations have started to provide a framework
to study basic and fundamental principles. New ideas and hypotheses can be
first analyzed with the computer simulations to help plan and analyze
experimental testing. The scope of the presentation will be to introduce
current device technologies, review some experimental studies, and discuss
how computer models can help in the design of better antitachycardia
devices.
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