It is well established that calcium is the prime trigger for secretion, both in neurons (synaptic transmission) and in neuro-endocrine cells (hormone secretion). However, cell calcium is divided into multiple pools by buffering, spatial gradients, sequestration in internal organelles, and spatial co-localization of ion channels and calcium-binding effector sites. Differences in these features and consequent differences in the dynamics of neuro-transmitter and hormone secretion will be addressed.

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