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Talk Abstract
Calcium Triggers Secretion, But Which Calcium and How?

Artie Sherman, NIH Mathematical Research Branch, NIDDK

It is well established that calcium is the prime trigger for secretion, both in neurons (synaptic transmission) and in neuro-endocrine cells (hormone secretion). However, cell calcium is divided into multiple pools by buffering, spatial gradients, sequestration in internal organelles, and spatial co-localization of ion channels and calcium-binding effector sites. Differences in these features and consequent differences in the dynamics of neuro-transmitter and hormone secretion will be addressed.

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