Inositol 1,4,5-trisphosphate (IP3)-induced intracellular Ca²⁺ release is an excitable process which mediates the effects of activated hormone and neurotransmitter pathways. Ca²⁺-induced Ca²⁺ release (CICR) from the IP3-bound IP3 receptor (IP3R) is the fundamental property which generates propagating Ca²⁺ waves when coupled to Ca²⁺ diffusion. These waves annihilate upon collision primarily due to Ca²⁺ inhibition of Ca²⁺ release at high Ca²⁺ concentrations. Since intracellular Ca²⁺ release is clearly controlled by Ca²⁺ feedback mechanisms, by necessity, any cellular process which binds, sequesters, and/or pumps intracellular Ca²⁺ will affect the dynamics of Ca²⁺ signalling. My talk will focus on the molecular control of Ca²⁺ signalling by Ca²⁺ binding proteins (CaBPs), Ca²⁺-ATPases, and mitochondria in Xenopus oocytes.

Back to Workshop Schedule