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Talk abstract:
Repetitive Paroxysmal Tachycardia – Mechanism and Control
Leon Glass, McGill University
Repetitive parosxysmal tachycardia is a term used by Parkinson and
Papp in 1947 to describe the repeated initiation and termination of
short episodes of rapid heart beats. I describe three different
experimental models that show repeated bursts of relatively rapid
activity: a ball of pacemaker cells that is stimulated at a fixed
delay after an action potential; an experimental model of accessory
pathway created by stimulating the atria at a fixed delay after
activation of the ventricles; a preparation of cultured heart cells
that shows spontaneous initiation and termination of rotating waves.
These three systems share common properties of intrinsic pacemaking
activity, a reentrant loop, and loss of excitability as a consequence
of rapid activation. Based on the above mechanism, methods to control
or eliminate the rhythm are immediately suggested.
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