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IMA Workshop
Cardiac Dynamics
March 9-14, 1998


Organizers:

Jim Collins, Chair
James Keener
Charles Peskin
Rai Winslow

Spatio-temporal patterns of electrical activity over the heart cause the muscle to contract. This workshop considered the electrical activity of the heart, and the resulting mechanical events, in both health and disease. It also reviewed current understanding and modeling of drug action. Simplified models of the electrical activity show normal wave propagation, as well as arrhythmias such as spontaneous spiral wave generation. Complicating factors for electrical and mechanical modelers include differing nonlinear properties in different regions, anisotropy in the conduction pathways and in the fiber architecture of the heart, and branching in the Purkinje system which triggers the muscle electrical activity. Large scale 3-D computational models for electrical and mechanical activity of the heart as well as reduced electrical models based on singular perturbation descriptions and kinematics of spiral cores have led to insights into cardiac physiology, and for excitable media more generally.

Click on the titles to find abstracts and/or links to presentation materials

SCHEDULE for MONDAY, MARCH 9
W. Miller, F. Dulles,
J. Collins
Welcome and Orientation
J. P. Keener,
University of Utah
Introduction to the Electrophysiology of Cardiac Tissue, I
Charles S. Peskin,
Courant Institute, NYU
Introduction to Cardiac Mechanics, I: The Heart in the Circulation
J. P. Keener,
University of Utah
Introduction to the Electrophysiology of Cardiac Tissue, II
SCHEDULE for TUESDAY, MARCH 10
Charles S. Peskin,
Courant Institute, NYU
Introduction to Cardiac Mechanics, II: Cardiac Fluid and Tissue Mechanics
J. P. Keener,
University of Utah
Introduction to the Electrophysiology of Cardiac Tissue, IIIi
Charles S. Peskin,
Courant Institute, NYU
Introduction to Cardiac Mechanics, III: Fiber Architecture of the Heart and its Valves
SCHEDULE for WEDNESDAY, MARCH 11
Yoram Rudy,
Case Western Reserve Univ.
Cardiac conduction: an interplay between membrane processes and structural properties
Saleet Jafri,
Johns Hopkins Univ. Sch. of Medicine
Modeling Cardiac Excitation-Contraction Coupling: New Insights into Interval-Force Relations
Chris Johnson,
University of Utah
Bioelectric field modeling, simulation and visualization
SCHEDULE for THURSDAY, MARCH 12
Cardiac Mechanics
Charles S. Peskin and David McQueen,
Courant Institute, NYU
Cardiac Mechanics by the Immersed Boundary Method
Andrew McCulloch,
Univ. of California-San Diego
Three-Dimensional Electromechanical Interactions in the Heart
Giovanna Cacciola,
Eindhoven Univ. of Technology
Numerical simulation of leaflet movement in a fiber-reinforced polymer heart valve prosthesis
Larry A. Taber,
Washington University
Modeling Strategies for Cardiac Development
Beth Feller Printz
Columbia University
Effects of Mitral Apparatus Geometry on Mitral Flow and Leaflet Motion: A Computer Study
SCHEDULE for FRIDAY, MARCH 13
Control of Cardiac Arrhythmias
Leon Glass
McGill University
Repetitive Paroxysmal Tachycardia -- Mechanism and Control
Alain Karma,
Northeastern University
Spatiotemporal control of reentrant tachycardias
Milton M. Morris,
Guidant Corporation
Math Considerations in Detection and Classification of Cardiac Arrhythmias in a Dual Chamber Implantable Cardioverter Defibrillator: Robustness vs. Device Longevity
Eddy Warman,
Medtronic Inc.
The role of modeling in the design of antitachycardia implantable devices
Shirley Xiaoyi Min,
Medtronic, Inc.
Relationship between Anatomy and Ventricular Defibrillation Thresholds in Two Finite-Element Human Thorax Models
Rahul Mehra,
Medtronic, Inc.
Discussion Session
SCHEDULE for SATURDAY, MARCH 14
Dirk J. Snyders,
Vanderbilt Univ. School of Medicine
K+-channels as molecular targets for antiarrhythmic drugs. Molecular mechanisms of drug action
Randall L. Rasmusson,
Allegheny Univ. of the Health Sciences
Modeling Conformation-Specific Potassium Channel Block
Lisa Irvine,
Johns Hopkins University
A new cardiac sodium channel Markov model for describing drug action
Anthony Varghese,
Oxford University
Block of Sodium Current and Cardiac Conduction

 

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1997-1998 Emerging Applications of Dynamical Systems

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