Talk abstract:

Dynamics of Within-Host Evolution of HIV-1

Nikolaos I. Stilianakis
Department of Medical Biometry
University of Tuebingen
Westbahnhofstr. 55
72070 Tuebingen
Germany
nist@uni-tuebingen.de

According to the mathematical model presented here the dynamics of HIV-1 infection can be explained by two simultaneous processes. Direct infection of CD4+ T-cell populations and ongoing generation and selection of HIV-1 variants with increasing reproductivity. Analysis of the model shows that the model can reproduce quantitatively some of the most striking findings concerning the pathegenesis of AIDS, including the long and variable incubation period.

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1998-1999 Mathematics in Biology