Laboratory of Kidney and Electrolyte Metabolism
NHLBI, and Mathematical Research Branch, NIDDK
National Institutes of Health
Bethesda, MD 20892-2690
Research in epithelial transport is being advanced by the identification, location, and study of proteins that allow for transport of species through lipid membranes.
Models of the urine concentrating mechanism are now used to quantitate the effect of changes in these transporters within normal and pathological states. Furthermore, the distribution of certain proteins within the rat kidney (e.g. AQP1, AQP2, BSC1, TSC, UT-A1, UT-A2, ClC-K1) is utilized to estimate transport parameters as well as identify renal morphometry.
We shall describe examples of the use of tools of molecular biology in conjunction with new physiological observations to refine the models.