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Tak Abstract
Viral and CD4 T Cell Demographics and Dynamics
in Lymphatic Tissues in HIV-1 Infection

Ashley T. Haase
Department of Microbiology
University of Minnesota

The lymphatic tissues (LTs) are the major reservoir and site where HIV-1 is produced, stored, and persists, and the organ system where >98 percent of the CD4+ T cells reside. I will first describe experimental measurements of LT populations of productively infected cells, chronically infected cells, and virus stored in the follicular dendritic cell (FDC) network in LTs in HIV-1-infected individuals, and then changes in these populations following highly active antiretroviral therapy (HAART). I will also discuss the impact of HIV-1 infection on CD4+ T cell populations in LT and the changes effected by HAART, and present an accounting-sheet model of credits and debits in the system related to supply, proliferation, trafficking, programmed cell death and removal, and the additional losses of infected CD4+ T cells in HIV-1 infection.

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1998-1999 Mathematics in Biology