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Winter 1999

IMA Workshop:

Endocrinology: Mechanism of Hormone Secretion and Control

February 15-19, 1999

 Organizers:

Albert Goldbeter
Universite Libre de Bruxelles
agoldbet@ulb.ac.be


Arthur Sherman
National Institutes of Health
asherman@nih.gov
WWW: http://mrb.niddk.nih.gov/sherman/

and

James Sneyd
University of Michigan
jsneyd@math.lsa.umich.edu
http://www.math.lsa.umich.edu/~jsneyd


Schedule Participants Registration
Material from Workshop


This workshop will study the mechanisms and control of hormone release, ranging from the receptor level through to whole body control, pulsatile secretions and dynamical disease. Although each of these topics has been studied in detail, there have been relatively few attempts to study the coordination and intersections of the mechanisms at different levels.

The workshop topics will include models for receptor adaptation, bursting electrical activity, action potentials in neuroendocrine cells, the importance of calcium for secretion, mechanisms of pulsatile hormonal secretion, hormonal control systems, whole-body feedback processes and dynamical diseases.

These topics are studied using a variety of mathematical techniques, of which ordinary differential equations, delay equations, bifurcation theory and qualitative analysis are the most important.

Tutorial

There will be a tutorial on Sunday, the 14th of February. The tutorial will consist of four one-hour talks.

TUTORIAL SCHEDULE

All talks are in Lecture Hall EE/CS 3-180 unless otherwise noted.

SUNDAY, FEBRUARY 14
James Sneyd, Chair
10:00-11:00 am James Sneyd
University of Michigan 		General Overview. Basic Electrophysiology. Calcium and IP3.
2:00-3:00 pm Andrew P. Le Beau
National Institutes of Health 		Neurosecretory Cells
3:00-4:00 pm Albert Goldbetter
Universite Libre de Bruxelles 		Pulsatile Secretion



WORKSHOP SCHEDULE

All talks are in Lecture Hall EE/CS 3-180 unless otherwise noted.

Monday Tuesday Wednesday Thursday Friday

MONDAY, FEBRUARY 15
Robert M. Miura, Chair
8:30 am Registration and Coffee Reception Room EE/CS 3-176
9:10 am Willard Miller, Fred Dulles
and James Sneyd		 Introduction
9:30 am Illani Atwater
National Institute of Health 		Basic Biophysical Properties of the Pancreatic -cell
10:30 am Coffee Break Reception Room EE/CS 3-176
11:00 am Keith Tornheim
Boston University Medical Center 		Glycolytic Oscillations and Insulin Secretion
12:00 noon Lunch  
1:30 pm Fredrick Van Goor
National Institute of Health 		Endoplasmic Reticulum Ca2+ Store Depletion Regulates Membrane Excitability in GNRH-Secreting Neurons
2:30 pm Coffee Break Reception Room EE/CS 3-176
2:45 pm Eli Ipp
Harbor-UCLA Medical Center 		Isulin and Other Metabolic Oscillations: in vitro and in vivo Perspectives
4:00 pm IMA Tea IMA East, 400 Lind Hall
A variety of appetizers and beverages will be served.
TUESDAY, FEBRUARY 16
James Sneyd, Chair
9:15 am Coffee Reception Room EE/CS 3-176
9:30 am Andrew Charles
University of California-Los Angeles 		Mechanisms of Spontaneous Rhythmic Activity in Pituitary and Hypothalamic Cells
10:30 am Coffee Break Reception Room EE/CS 3-176
11:00 am Robert M. Miura
University of British Columbia 		The -Cell Mass, Insulin, and Glucose Model: Pathways to Diabetes
12:00 noon Lunch  
2:00 pm David Brown
The Babraham Institute 		Vasopressin and Oxytocin Neurons - Similar Neurosecretory Cells with Different Patterns of Activity and Hormone Release
3:00 pm Coffee Break Reception Room EE/CS 3-176
3:30-3:50 pm Isabella Susa
Universite Libre de Bruxelles 		The Sodium/Calcium Exchanger Affects the Plateau Fraction in Models for Electrical Bursting in Pancreatic -cells
3:50-4:10 pm Mark Pernarowski
Montana State University 		Controllability of Excitable Systems
4:10-4:20 pm Coffee Break Reception Room EE/CS 3-176
4:20-4:40 pm Joe Mahaffy
San Diego State University 		A Mathematical Model for Erythropoiesis
4:40-5:00 pm Andrew P. Le Beau
National Institutes of Health 		On the Control of Action Potential Firing Frequency in Hypothalamic GT1 Neurons
WEDNESDAY, FEBRUARY 17
James Sneyd, Chair
9:15 am Coffee Reception Room EE/CS 3-176
9:30 am Michael J. Quon
NIH 		Mathematical Modeling of Insulin Action and In Vivo Estimates of Insulin Sensitivity
10:30 am Coffee Break Reception Room EE/CS 3-176
11:00 am Diane Finegood
Simon Frasier University 		Investigating b-cell Mass Dynamics with a Mass Balance Model
12:00 noon Lunch  
2:00 pm Stanko Stojilkovic
National Institute of Health 		Spontaneous and Receptor-controled Pacemaker Activity and Growth Hormone Secretion in Pituitary Somatotrophs
3:00 pm Coffee Break Reception Room EE/CS 3-176
3:30-3:50 pm David J.N. Wall
University of Canterbury 		Mathematical Models of Corticotroph Cells
3:50-4:10 pm Yue-Xian Li
University of British Columbia 		Modeling Synchronized Calcium Oscillations in Pituitary Cells Coupled Through Gap Junctions
4:10-4:20 pm Coffee Break Reception Room EE/CS 3-176
4:20-4:40 pm Geneviève Dupont
University Libre de Bruxelles 		Theoretical Investigation of the Effect of Ca2+ Oscillations on the Balance Between Glycogen Synthesis and Degradation in the Liver
4:40-5:00 pm Gerda de Vries
Effect of Noise on the Emergent Collective Behaviour of Diffusively Coupled Biological Oscillators
THURSDAY, FEBRUARY 18
Albert Goldbetter, Chair
9:15 am Coffee Reception Room EE/CS 3-176
9:30 am Klaus Prank
New Analytical Approaches in the Classification of Endocrine Diseases
10:30 am Coffee Break Reception Room EE/CS 3-176
11:00 am Richard Bertram
Pennsylvania State University 		Phantom Bursting in Pancreatic -Cells
12:00 noon Lunch  
2:00 pm Jeppe Sturis
Pharmacological Research 1
Health Care Discovery 		Possible Mechanisms and Modulatory Factors Involved in Oscillatory Insulin Secretion
3:00 pm Coffee Break Reception Room EE/CS 3-176
3:30-3:50 pm Karen Heinze
Parke-Davis/Warner-Lambert Company 		A Mathematical Model of Luteinizing Hormone (LH) Release from Ovine Pitutitary Cells in Perfusion
3:50-4:10 pm Daniel Keenan
University of Virginia 		A Stochastic Biomathematical Model of the Male Reproductive Hormone System
4:10-4:20 pm Coffee Break Reception Room EE/CS 3-176
4:20-4:40 pm David Polidori
Entelos, Inc. 		Hormonal Secretion and Control in a Systems Context: A Large-Scale Model of Human Metabolism
6:00 pm Workshop Dinner Campus Club, 4th Floor Coffman Student Union
FRIDAY, FEBRUARY 19
Albert Goldbeter, Chair
9:15 am Coffee Reception Room EE/CS 3-176
9:30 am Bingzheng Liu
Northeast Normal University 		Chaotic Behavior of a Model of the Hypothalamo-pituitary-gonad Axis in Man
10:00 am James F. Selgrad
North Carolina State University 		A Model for Hormonal Regulation of the Menstrual Cycle
10:30 am Coffee Break Reception Room EE/CS 3-176
11:00 am Tamas Ördög
The GnRH Pulse Generator
12:00 noon Lunch  
2:00 pm Discussion
 
3:00 pm Tearful Farewells
 

Monday Tuesday Wednesday Thursday Friday

LIST OF CONFIRMED PARTICIPANTS

as of 2/12/99
Name Affiliation Department
Illani Atwater National Institute of Health LCB8, NIDDK
Richard Bertram Pennsylvania State University Behrend College
David Brown The Babraham Institute Laboratory of Computational Neuroscience
Andrew Charles University of California-Los Angeles Neurology
Jun Choe Korea Advanced Institute of Science & Technology Mathematics
Jim Costantin Univerwity of California-Los Angeles Neurology
Gerda DeVries University of Alberta Mathematical Sciences
Genevieve Dupont University Libre de Bruxelles  
Diane Finegood Simon Frasier University Kinesiology
Albert Goldbeter Universite Libre de Bruxelles Faculte des Sciences
Shay Gueron Technion-I.I.T. Mathematics
Karen Heinze Parke-Davis/Warner-Lambert Company  
Eli Ipp Harbor-UCLA Medical Center Medicine
Daniel Keenan University of Virginia Mathematics
Mary Anne Kiel University of Texas - San Antonio Mathematics and Statistics
Andrew Le Beau NIDDK Mathematical Research Branch
Yue-Xian Li University of British Columbia Mathematics
Bing-Zheng Liu Northeast Normal University Physics
Danielle Lyles University of Texas - San Antonio Mathematics and Statistics
Joe Mahaffy San Diego State University Mathematics Sciences
Cheryl McDonald Simon Frasier University  
Robert Miura National Institute of Diabetes & Digestive and Kidney Disease Mathematics Research Branch
Tamas Ördög University of Nevada School of Medicine Physiology and Cell Biology
Mark Pernarowski Montana State University Mathematical Sciences
David Polidori Entelos, Inc. Biological Systems Modeling
Klaus Prank Medical School Hannover Clinical Endocrinology
Michael Quon National Heart, Lung and Blood Institute Hypertension-Endocrine Branch
Hashim A. Saber University of Pittsburgh Mathematics
James F. Selgrade North Carolina University Mathematics
Crispin J Semakula University of Minnesota Medicine/Endocrinology & Metabolism
Arthur Sherman National Institute of Health Mathematical Research Branch, NIDDK
James Sneyd University of Michigan Mathematics
Stanko Stojilkovich NIH Endocrine and Reproductive Research Branch
Jeppe Sturis University of Chicago Medicine
Isabella Susa Universite Libre de Bruxelles Faculte des Sciences
Keith Tornheim Boston University Medical Center Biochemistry
Fredrick Van Goor National Institute of Health  
David Wall University of Canterbury Mathematics and Statistics
Tarynn Witten UT HSC San Antonio Community Dentistry
Hui Yang Northeast Normal University Mathematics
Michael G. Zager Chemical Industry Institute of Toxicology Endocrine Research in Developmental Toxicology
Mary Lou Zeeman University of Texas at San Antonio Mathematics and Statistics



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1998-1999 Mathematics in Biology

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