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IMA Workshop
Cell Adhesion and Motility
January 4-8, 1999


Organizers:

Wolfgang Alt
Abteilung Theoretische Biologie
Botanisches Institut der Universitaet Bonn
Kirschallee 1
D-53115 BONN
Germany
wolf.alt@uni-bonn.de
http://www.theobio.uni-bonn.de

and

Robert T. Tranquillo
University of Minnesota
tranquillo@cems.umn.edu
http://www.cems.umn.edu/people/faculty/tranquil.html,


Cell adhesion and motility are vital to many physiological processes, such as inflammation, wound healing and metastasis, as well as biotechnology applications (e.g. cell-adhesion-based separation and purification) and the nascent field of tissue engineering, where achieving and controlling the cellularity of bioartificial tissues is critical.

The advent of cell and molecular biology has enabled the development of mechanistic models relating molecular properties such as integrin-mediated adhesion and F-actin regulated motility to these cell functions. However, much remains to be accomplished, especially in developing models that make explicit account for the role of adhesion in cell migration, in external fields (e.g. gradients of adhesion or chemotactic factor molecules, or aligned extracellular matrix fibers). Exploiting the ability to now manipulate molecular properties of the cell and create such fields affords profound opportunities for model validation and development. In addition to assembling a group of investigators who can pioneer such models and their testing, another focus will be on examining the origin and role of stochasticity that is manifest in cell adhesion and motility and to discuss diffusion approximation methods that can be applied to stochastic mechanistic models in order to obtain more tractable PDE formulations.



WORKSHOP SCHEDULE

All talks are in Lecture Hall EE/CS 3-180 unless otherwise noted.

Monday Tuesday Wednesday Thursday Friday

MONDAY, JANUARY 4
8:30 am Registration and Coffee Reception Room EE/CS 3-176
9:10 am Willard Miller, Fred Dulles and Robert Tranquillo Introduction
9:30 am Graham A. Dunn
King's College London
Using Microinterferometry to Study the Function of the Cytoskeleton in Cell Motility
10:30 am Coffee Break Reception Room EE/CS 3-176
11:00 am Wolfgang Alt
Universitaet Bonn
Lamellipod and Ruffle Dynamics of Human Epidermal Keratinocytes - Data Analysis, Models and Simulations
3:00 pm Michael Sheetz
Duke University
Forces In and On Membranes Alter Motility and Adhesion
4:00 pm IMA Tea IMA East, 400 Lind Hall
A variety of appetizers and beverages will be served.
TUESDAY, JANUARY 5
9:15 am Coffee Break Reception Room EE/CS 3-176
9:30 am Geert W. Schmid-Schönbein
University of California, San Diego
A Mechanism for the Control of the Shear Stress Response in Circulating Leukocytes
10:30 am Coffee Break Reception Room EE/CS 3-176
11:00 am Paul Janmey
Harvard University
Network and Bundle Formation by Semi-flexible Biopolymers: F-actin and Filamentous Viruses
Note, the following talk is part of the Department of Chemical Engineering and Materials Science Seminar Series, and will take place in B75 Amundson Hall.
1:25 pm Daniel A. Hammer
University of Pennsylvania
Soft Materials Inspired by Biology
3:00 pm Micah Dembo
Boston University
Cytokinesis and the Dynamics of the Cytoskeleton
WEDNESDAY, JANUARY 6
9:15 am Coffee Break Reception Room EE/CS 3-176
9:30 am Leah Edelstein-Keshet
University of British Columbia
Models for the Structure and Kinetics of Actin Filaments
10:30 am Coffee Break Reception Room EE/CS 3-176
11:00 am Yu-li Wang
University of Massachusetts Medical School
High Resolution Mapping of Stresses at the Cell-Substrate Interface During Locomotion of Fibroblasts
1:30-3:30 pm Poster/Software/Video Session Lind Hall 400 & 409
THURSDAY, JANUARY 7
9:15 am Coffee Break Reception Room EE/CS 3-176
9:30 am Ralph Nossal
National Institutes of Health (NIH)
Regulation of Cell Surfaces by Receptor Mediated Endocytosis
10:30 am Coffee Break Reception Room EE/CS 3-176
11:00 am Helen M. Buettner
Rutgers University
Neuronal Growth Cone Motility: A Case Study in Organized Complexity
Joint Seminar in Mathematics and Biology
Millard Hall 5-276A
12:00 noon Bill Holmes
Ohio University
Models of Calmodulin Trapping and CaM Kinas II Activation in a Dendritic Spine
Computational Biological Sciences Colloquium Series
School of Mathematics, Vincent Hall Room 16
3:30 pm Hans G. Othmer
University of Utah
A Biological Problem Viewed Through the Lens of Mathematics: Pattern Formation and Morphogenesis in Early Development
6:00 pm Cell Adhesion and Motility Workshop Dinner Taylor Room, 150 Lind Hall
FRIDAY, JANUARY 8
9:15 am Coffee Break Reception Room EE/CS 3-176
9:30 am Jacob Israelachvili
University of California, Santa Barbara
Measurements of Adhesion of Biological Molecules and Surfaces: How it Differs from Non-biological Adhesion
10:30 am Coffee Break Reception Room EE/CS 3-176
11:00 am Daniel A. Hammer
University of Pennsylvania
Adhesive Dynamics: Solved and Unsolved Problems
1:30 pm Conclusion/Discussion  

Monday Tuesday Wednesday Thursday Friday



LIST OF CONFIRMED PARTICIPANTS

as of 12/15/98
Name
Affiliation
Department
Wolfgang Alt Universitaet Bonn Abteilung Theoretische Biologie
Daniel Bentil University of Vermont Department of Mathematics & Statistics
Dean Bottino University of Utah Department of Mathematics
Till Bretschneider Universitaet Bonn Theoretische Biologie
Helen Buettner Rutgers University Department of Chemical and Biochemical Engineering
Jun Choe Korea Advanced Institute of Science & Technology Department of Mathematics
Micah Dembo Boston University Department of Biomedical Engineering
Rich Dickinson University of Florida Chemical Engineering Department
Graham Dunn Kings College London The Randall Institute
Leah Edelstein-Keshet University of British Columbia Department of Mathematics
Daniel A. Hammer University of Pennsylvania Department of Chemical Engineering
Robert Hochmuth Duke University Department of Mechanical Engineering & Materials Science
Jacob N. Israelachvili University of California Santa Barbara Department of Chemical Engineering
Paul Janmey Harvard Medical School Brigham and Womens Hospital
Leah Keshet University of British Columbia Department of Mathematics
Sharon Lubkin North Carolina State University Biomathematics Program
Alex Mogilner University of California - Davis Department of Mathematics
Ralph Nossal National Institutes of Health (NIH)  
Dave Odde Michigan Tech Department of Chemical Engineering
Hans Othmer University of Utah Department of Mathematics
Sean Palecek University of Chicago  
Eirikur Palsson University of Utah Department of Mathematics
Geert Schmid-Schoenbein University of California, San Diego Department of Bioengineering
Mike Sheetz Duke University Department of Cell Biology
Robert Tranquillo University of Minnesota Department of Chem. Eng. and Material Sciences
Arpita Upadhyaya University of Notre Dame Department of Physics
Yu-Li Wang University of Massachusetts Medical School
Harvey Williams Tulane University Mathematics & Biomedical Engineering
Zhu Cheng Georgia Tech Mechanical Engineering Department
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