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Winter
1999 |
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| Schedule | Participants | Registration |
Cell adhesion and motility are vital to many physiological processes, such as inflammation, wound healing and metastasis, as well as biotechnology applications (e.g. cell-adhesion-based separation and purification) and the nascent field of tissue engineering, where achieving and controlling the cellularity of bioartificial tissues is critical.
The advent of cell and molecular biology has enabled the development of mechanistic models relating molecular properties such as integrin-mediated adhesion and F-actin regulated motility to these cell functions. However, much remains to be accomplished, especially in developing models that make explicit account for the role of adhesion in cell migration, in external fields (e.g. gradients of adhesion or chemotactic factor molecules, or aligned extracellular matrix fibers). Exploiting the ability to now manipulate molecular properties of the cell and create such fields affords profound opportunities for model validation and development. In addition to assembling a group of investigators who can pioneer such models and their testing, another focus will be on examining the origin and role of stochasticity that is manifest in cell adhesion and motility and to discuss diffusion approximation methods that can be applied to stochastic mechanistic models in order to obtain more tractable PDE formulations.
WORKSHOP SCHEDULE
All
talks are in Lecture Hall EE/CS 3-180 unless otherwise noted.
| Monday | Tuesday | Wednesday | Thursday | Friday |
| MONDAY, JANUARY 4 | ||
|---|---|---|
| 8:30 am | Registration and Coffee | Reception Room EE/CS 3-176 |
| 9:10 am | Willard Miller, Fred Dulles and Robert Tranquillo | Introduction |
| 9:30 am | Graham
A. Dunn King's College London |
Using Microinterferometry to Study the Function of the Cytoskeleton in Cell Motility |
| 10:30 am | Coffee Break | Reception Room EE/CS 3-176 |
| 11:00 am | Wolfgang
Alt Universitaet Bonn |
Lamellipod and Ruffle Dynamics of Human Epidermal Keratinocytes - Data Analysis, Models and Simulations |
| 3:00 pm |
Michael Sheetz Duke University |
Forces In and On Membranes Alter Motility and Adhesion |
| 4:00 pm | IMA Tea |
IMA East, 400 Lind Hall A variety of appetizers and beverages will be served. |
| TUESDAY, JANUARY 5 | ||
| 9:15 am | Coffee Break | Reception Room EE/CS 3-176 |
| 9:30 am | Geert
W. Schmid-Schönbein University of California, San Diego |
A Mechanism for the Control of the Shear Stress Response in Circulating Leukocytes |
| 10:30 am | Coffee Break | Reception Room EE/CS 3-176 |
| 11:00 am |
Paul Janmey Harvard University |
Network and Bundle Formation by Semi-flexible Biopolymers: F-actin and Filamentous Viruses |
| Note, the following talk is part of the Department of Chemical Engineering and Materials Science Seminar Series, and will take place in B75 Amundson Hall. | ||
| 1:25 pm | Daniel
A. Hammer University of Pennsylvania |
Soft Materials Inspired by Biology |
| 3:00 pm | Micah
Dembo Boston University |
Cytokinesis and the Dynamics of the Cytoskeleton |
| WEDNESDAY, JANUARY 6 | ||
| 9:15 am | Coffee Break | Reception Room EE/CS 3-176 |
| 9:30 am | Leah
Edelstein-Keshet University of British Columbia |
Models for the Structure and Kinetics of Actin Filaments |
| 10:30 am | Coffee Break | Reception Room EE/CS 3-176 |
| 11:00 am | Yu-li
Wang University of Massachusetts Medical School |
High Resolution Mapping of Stresses at the Cell-Substrate Interface During Locomotion of Fibroblasts |
| 1:30-3:30 pm | Poster/Software/Video Session | Lind Hall 400 & 409 |
| THURSDAY, JANUARY 7 | ||
| 9:15 am | Coffee Break | Reception Room EE/CS 3-176 |
| 9:30 am |
Ralph Nossal National Institutes of Health (NIH) |
Regulation of Cell Surfaces by Receptor Mediated Endocytosis |
| 10:30 am | Coffee Break | Reception Room EE/CS 3-176 |
| 11:00 am | Helen
M. Buettner Rutgers University |
Neuronal Growth Cone Motility: A Case Study in Organized Complexity |
|
Joint Seminar in Mathematics and
Biology Millard Hall 5-276A |
||
| 12:00 noon |
Bill Holmes Ohio University |
Models of Calmodulin Trapping and CaM Kinas II Activation in a Dendritic Spine |
|
Computational Biological Sciences
Colloquium Series School of Mathematics, Vincent Hall Room 16 |
||
| 3:30 pm | Hans
G. Othmer University of Utah |
A Biological Problem Viewed Through the Lens of Mathematics: Pattern Formation and Morphogenesis in Early Development |
| 6:00 pm | Cell Adhesion and Motility Workshop Dinner | Taylor Room, 150 Lind Hall |
| FRIDAY, JANUARY 8 | ||
| 9:15 am | Coffee Break | Reception Room EE/CS 3-176 |
| 9:30 am | Jacob
Israelachvili University of California, Santa Barbara |
Measurements of Adhesion of Biological Molecules and Surfaces: How it Differs from Non-biological Adhesion |
| 10:30 am | Coffee Break | Reception Room EE/CS 3-176 | 11:00 am | Daniel
A. Hammer University of Pennsylvania |
Adhesive Dynamics: Solved and Unsolved Problems |
| 1:30 pm | Conclusion/Discussion | |
| Monday | Tuesday | Wednesday | Thursday | Friday |
LIST
OF CONFIRMED PARTICIPANTS
as
of 12/15/98
|
Name
|
Affiliation
|
Department
|
| Wolfgang Alt | Universitaet Bonn | Abteilung Theoretische Biologie |
| Daniel Bentil | University of Vermont | Department of Mathematics & Statistics |
| Dean Bottino | University of Utah | Department of Mathematics |
| Till Bretschneider | Universitaet Bonn | Theoretische Biologie |
| Helen Buettner | Rutgers University | Department of Chemical and Biochemical Engineering |
| Jun Choe | Korea Advanced Institute of Science & Technology | Department of Mathematics |
| Micah Dembo | Boston University | Department of Biomedical Engineering |
| Rich Dickinson | University of Florida | Chemical Engineering Department |
| Graham Dunn | Kings College London | The Randall Institute |
| Leah Edelstein-Keshet | University of British Columbia | Department of Mathematics |
| Daniel A. Hammer | University of Pennsylvania | Department of Chemical Engineering |
| Robert Hochmuth | Duke University | Department of Mechanical Engineering & Materials Science |
| Jacob N. Israelachvili | University of California Santa Barbara | Department of Chemical Engineering |
| Paul Janmey | Harvard Medical School | Brigham and Womens Hospital |
| Leah Keshet | University of British Columbia | Department of Mathematics |
| Sharon Lubkin | North Carolina State University | Biomathematics Program |
| Alex Mogilner | University of California - Davis | Department of Mathematics |
| Ralph Nossal | National Institutes of Health (NIH) | |
| Dave Odde | Michigan Tech | Department of Chemical Engineering |
| Hans Othmer | University of Utah | Department of Mathematics |
| Sean Palecek | University of Chicago | |
| Eirikur Palsson | University of Utah | Department of Mathematics |
| Geert Schmid-Schoenbein | University of California, San Diego | Department of Bioengineering |
| Mike Sheetz | Duke University | Department of Cell Biology |
| Robert Tranquillo | University of Minnesota | Department of Chem. Eng. and Material Sciences |
| Arpita Upadhyaya | University of Notre Dame | Department of Physics |
| Yu-Li Wang | University of Massachusetts | Medical School |
| Harvey Williams | Tulane University | Mathematics & Biomedical Engineering |
| Zhu Cheng | Georgia Tech | Mechanical Engineering Department |
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