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IMA Minisymposium
Cancer
November 15-19, 1998


Organizer:

Philip Maini
University of Oxford
Mathematics Institute
maini@maths.ox.ac.uk


Cancer is the second biggest killer in the western world and its incidence is rapidly increasing. Despite the huge proliferation of experimental data and clinical treatments there has been no decrease in the death rates due to the most common cancers. This is due largely to the fact that there is still no basic consenses model of tumour growth and survival, metastasis (the process whereby potentially fatal secondary tumours are formed from a primary tumour), tumour angiogensis (whereby nutrients are diverted to the tumour), or extracellular matrix breakdown by tumour cells. One of the challenges of the next decade is to develop mathematical models which clarify these fundamental processes and which can predict new strategies of clinical therapy.

The aim of this workshop is to invite a small group of clinicians, experimentalists and theoreticians working in this area to present their latest research findings and to identify possible areas in which cross-disciplinary collaboration may be fruitful.

Workshop will consist of three days of talks. We encourage participants to stay another two days for informal discussion.

MINISYMPOSIUM SCHEDULE

All talks are in Lecture Hall EE/CS 3-180 unless otherwise noted.

Sunday Monday Tuesday Wednesday

SUNDAY, NOVEMBER 15
9:30 am Registration and Coffee Reception Room EE/CS 3-176
9:45 am Willard Miller, Fred Dulles
and Philip Maini
Brief Introduction
10:00 am John A. Adam
Old Dominion University
Mathematical Modeling of Tumor Growth: Synopsis, Simile & Speculation
11:00 am Coffee Break Reception Room EE/CS 3-176
11:15 am Robert Gatenby
Temple University
An Acid Mediated Model of Tumor Invasion
2:00 pm Abbey Perumpanani
Harvard Medical School
Cell - ECM Interactions During Malignant Invasion
MONDAY, NOVEMBER 16
9:15 am Coffee IMA East Lind Hall 409
9:30 am Helen Byrne
University of Nottingham
Free Boundaries in Solid Tumour Growth
10:30 am Coffee Break Reception Room EE/CS 3-176
11:00 am Trachette Jackson
University of Minnesota
Mathematical Models in Two-Step Cancer Chemotherapy
2:00 pm Avner Friedman
University of Minnesota
Analysis of a Mathematical Model of the Effect of Inhibitors on the Growth of Tumors
3:00 pm Coffee Break IMA East Lind Hall 400
3:15 pm Lawrence M. Wein
MIT Sloan Schol of Management
Mathematical Modeling and Analysis of a Replication-competent Adenovirus that Replicates Selectively in Tumor Cells: Implications for Design and Delivery
4:15 pm IMA Tea
A variety of appetizers and beverages will be served.
IMA East, 400 Lind Hall
TUESDAY, NOVEMBER 17
10:30 am Coffee Break IMA East Lind Hall 409
9:30 am Helen Byrne
University of Nottingham
Modelling Tumour Angiogenesis
10:30 am Coffee Break Reception Room EE/CS 3-176
11:00 am Howard A Levine
Iowa State University
A Mathematical Model for Angiogenesis in Tumor Growth
12:20 pm Lee Segel
Weizman Institute of Science
School of Mathematics Ordway Lectures
Vincent Hall 570
Modeling Weed Resistance to Herbicides
2:00 pm Sabine Stoecker
Politecnico di Torino
Kinetic Cellular Theory of the Immune System: Modeling, Experiments and Simulation
WEDNESDAY, NOVEMBER 18
10:00 am Coffee IMA East Lind Hall 400
2:00 pm Catherine Verfaillie
University of Minnesota
Chronic Myelogenous Leukemia: a Disease Caused by Abnormal Adhesion of Stem Cells to the Marrow Microenvironment

Sunday Monday Tuesday Wednesday



LIST OF CONFIRMED PARTICIPANTS

Name
Affiliation
Department
John A. Adam Old Dominion University Department of Mathematics and Statistics
Helen Byrne University of Nottingham School of Mathematical Sciences
Avner Friedman University of Minnesota Minnesota Center for Industrial Mathematics
Robert Gatenby Temple University Department of Diagnostic Imaging
Trachette Jackson University of Minnesota Institute for Mathematics and its Applications
Howard A. Levine Iowa State University Department of Mathematics
Philip Maini University of Oxford Mathematics Institute
Abbey Perumpanani Harvard Medical School  
Sundaram Ramakrishnan University of Minnesota Department of Pharmacology
Fernando Reitich University of Minnesota School of Mathematics
Sabine Stocker Politecnico di Torino  
Catherine Verfaillie University of Minnesota Medical School
and IMA Postdocs and visitors in residence
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