Organizer:

Philip Maini
University of Oxford
Mathematics Institute
maini@maths.ox.ac.uk

Cancer is the second biggest killer in the western world and its incidence is rapidly increasing. Despite the huge proliferation of experimental data and clinical treatments there has been no decrease in the death rates due to the most common cancers. This is due largely to the fact that there is still no basic consenses model of tumour growth and survival, metastasis (the process whereby potentially fatal secondary tumours are formed from a primary tumour), tumour angiogensis (whereby nutrients are diverted to the tumour), or extracellular matrix breakdown by tumour cells. One of the challenges of the next decade is to develop mathematical models which clarify these fundamental processes and which can predict new strategies of clinical therapy.

The aim of this workshop is to invite a small group of clinicians, experimentalists and theoreticians working in this area to present their latest research findings and to identify possible areas in which cross-disciplinary collaboration may be fruitful.

Workshop will consist of three days of talks. We encourage participants to stay another two days for informal discussion.

MINISYMPOSIUM SCHEDULE

All talks are in Lecture Hall EE/CS 3-180 unless otherwise noted.

Sunday

Monday

Tuesday

Wednesday

SUNDAY, NOVEMBER 15
9:30 am	Registration and Coffee	Reception Room EE/CS 3-176
9:45 am	Willard Miller, Fred Dulles and Philip Maini	Brief Introduction
10:00 am	John A. Adam Old Dominion University	Mathematical Modeling of Tumor Growth: Synopsis, Simile & Speculation
11:00 am	Coffee Break	Reception Room EE/CS 3-176
11:15 am	Robert Gatenby Temple University	An Acid Mediated Model of Tumor Invasion
2:00 pm	Abbey Perumpanani Harvard Medical School	Cell - ECM Interactions During Malignant Invasion
MONDAY, NOVEMBER 16
9:15 am	Coffee	IMA East Lind Hall 409
9:30 am	Helen Byrne University of Nottingham	Free Boundaries in Solid Tumour Growth
10:30 am	Coffee Break	Reception Room EE/CS 3-176
11:00 am	Trachette Jackson University of Minnesota	Mathematical Models in Two-Step Cancer Chemotherapy
2:00 pm	Avner Friedman University of Minnesota	Analysis of a Mathematical Model of the Effect of Inhibitors on the Growth of Tumors
3:00 pm	Coffee Break	IMA East Lind Hall 400
3:15 pm	Lawrence M. Wein MIT Sloan Schol of Management	Mathematical Modeling and Analysis of a Replication-competent Adenovirus that Replicates Selectively in Tumor Cells: Implications for Design and Delivery
4:15 pm	IMA Tea A variety of appetizers and beverages will be served.	IMA East, 400 Lind Hall
TUESDAY, NOVEMBER 17
10:30 am	Coffee Break	IMA East Lind Hall 409
9:30 am	Helen Byrne University of Nottingham	Modelling Tumour Angiogenesis
10:30 am	Coffee Break	Reception Room EE/CS 3-176
11:00 am	Howard A Levine Iowa State University	A Mathematical Model for Angiogenesis in Tumor Growth
12:20 pm	Lee Segel Weizman Institute of Science	School of Mathematics Ordway Lectures Vincent Hall 570 Modeling Weed Resistance to Herbicides
2:00 pm	Sabine Stoecker Politecnico di Torino	Kinetic Cellular Theory of the Immune System: Modeling, Experiments and Simulation
WEDNESDAY, NOVEMBER 18
10:00 am	Coffee	IMA East Lind Hall 400
2:00 pm	Catherine Verfaillie University of Minnesota	Chronic Myelogenous Leukemia: a Disease Caused by Abnormal Adhesion of Stem Cells to the Marrow Microenvironment

Sunday

Monday

Tuesday

Wednesday

LIST OF CONFIRMED PARTICIPANTS

Name	Affiliation	Department
John A. Adam	Old Dominion University	Department of Mathematics and Statistics
Helen Byrne	University of Nottingham	School of Mathematical Sciences
Avner Friedman	University of Minnesota	Minnesota Center for Industrial Mathematics
Robert Gatenby	Temple University	Department of Diagnostic Imaging
Trachette Jackson	University of Minnesota	Institute for Mathematics and its Applications
Howard A. Levine	Iowa State University	Department of Mathematics
Philip Maini	University of Oxford	Mathematics Institute
Abbey Perumpanani	Harvard Medical School
Sundaram Ramakrishnan	University of Minnesota	Department of Pharmacology
Fernando Reitich	University of Minnesota	School of Mathematics
Sabine Stocker	Politecnico di Torino
Catherine Verfaillie	University of Minnesota	Medical School
and IMA Postdocs and visitors in residence