Mathematical modeling

Tuesday, May 13, 2008 - 4:45pm - 5:45pm
James Liao (University of California, Los Angeles)
Engineering intracellular metabolism has a long history, dated back to the late 1950s. The field has enjoyed significant attention in recent years, particularly because of the energy and environmental concerns. Many success stories have highlighted the feasibility of engineering intracellular metabolism to achieve a designed function. In almost all cases, the bottleneck of the problem resides on the biological side.
Thursday, March 6, 2008 - 2:50pm - 3:30pm
H. Steven Wiley (Pacific Northwest National Laboratories)
The epidermal growth factor receptor (EGFR) is a central signal transduction pathway in epithelial cells and regulates diverse biological responses such as proliferation, migration and differentiation. Ligands for the EGFR, such as amphiregulin and TGFa are synthesized as membrane-anchored precursors and released by regulated proteolysis, leading to autocrine signaling. Ligand shedding is controlled by a number of different hormones and is responsible for EGFR “transactivation” or crosstalk.


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