Molecular Network Control Through Boolean Canalization

Friday, November 20, 2015 - 9:30am - 9:45am
Keller 3-180
David Murrugarra (University of Kentucky)
Boolean networks are an important class of computational models for molecular interaction networks. Boolean canalization, a type of hierarchical clustering of the inputs of a Boolean function, has been extensively studied in the context of network modeling where each layer of canalization adds a degree of stability in the dynamics of the network. Recently, dynamic network control approaches have been used for the design of new therapeutic interventions and for other applications such as stem cell reprogramming. This talk will discuss the role of canalization in the control of Boolean molecular networks. A method for identifying the potential control edges in the wiring diagram of a network for avoiding undesirable state transitions will be presented. The method is based on identifying appropriate input-output combinations on undesirable transitions that can be modified using the edges in the wiring diagram of the network. Moreover, a method for estimating the number of changed transitions in the state space of the system as a result of an edge deletion in the wiring diagram will be presented. These two complementary methods can help in the selection of appropriate controllers such as for minimizing the side effects resulting from an edge manipulation.
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