Entanglement is prevalent at many different scales in the natural sciences. The mathematical modeling of entanglement in DNA and proteins, for example, provide insights into their structure and properties. However, many fundamental questions are still unanswered and draw interest from both theoreticians and experimentalists across many disciplines. This session will draw a wide range of researchers interested in the interdisciplinary study of physical knotting and linking together with students and post-docs to share their progress and their challenges for the future.