Modern questions of biological science are becoming increasingly quantitative and microscopic, and increasingly approachable by physical models and computer simulations. This workshop is focused at the interface where molecular and cellular biology meet the mathematical and computational sciences. We will explore both principles and methodologies, particularly those that are rooted in physics and rigorous mathematics, in addition to applications to biological problems. Research topics will include the computational folding of proteins and other biomolecules, ligand docking, biological networks, heterogeneous dynamics, and complex systems. Speakers will be encouraged to present new work, and to identify important unsolved problems and opportunities at this interface.