Knowledge Discovery in Microarray Gene Expression Data

Wednesday, December 4, 2002 - 2:40pm - 3:30pm
Keller 3-180
Gregory Piatetsky-Shapiro (KDnuggets)
DNA Microarrays are revolutionizing molecular biology, allowing simultaneous analysis of many thousands of genes. Microarray hold the promise of important applications, including creating novel, genetic-based diagnostic tests, finding new molecular targets for therapy, and developing personalized treatments.

Microarrays allow analysis of dynamic processes and deeper insight into biological pathways.

However, the large number of genes and a typically small number of samples, present unique challenges for DNA microarray data analysis. We discuss issues in normalization of microarray data, selecting the best set of genes for classification and clustering, randomization techniques, and building classification and clustering models.

We illustrate these processes using a number of software tools and show new results with potential biological significance.